Bryan Clinical Research Center

Advancing knowledge through research

The mission of the Bryan Clinical Research Center is to advance knowledge through leading edge research, while promoting the health and well-being of research patients. The research center is committed to thoughtful collaboration with study sponsors, physicians, hospital services, clinics and research participants to provide cutting edge research to safely advance the health of current and future participants. 

What is clinical research, and is it right for you?

Clinical research is the comprehensive study of the safety and effectiveness of the most promising advances in patient care. It involves people who volunteer to help us better understand medicine and health. Every drug, device, tool, diagnostic test, technique and technology used in medicine today was once tested in volunteers who took part in clinical research studies.

Bryan’s Clinical Research Center offers studies for both outpatients and hospital inpatients. Participation is always voluntary, and participants can leave a study at any time for any reason.

Active Clinical Trials

The Bryan Clinical Research Center is currently managing the following clinical studies:

ALKS 2680-201, 202, 203, 301

Study Name: A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Narcolepsy Type 2 (Vibrance-2)
Study Sponsor: Alkermes
Principal Investigator: Kevin Reichmuth, MD

Description: A Phase 2, Parallel-Group, Dose-Range-Finding Study with Randomized Double-Blind Treatment and Open-Label Periods to Evaluate the Safety and Efficacy of ALKS 2680 in Subjects with Narcolepsy Type 1, 2, IH, open label (respectively).

Status: Currently enrolling

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Beads Vs Vac

Study Name: Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy (Beads vs Vac)
Study Sponsor: University of Maryland, Baltimore; Funded by: US Department of Defense
Principal Investigator: Alesha Scott, DO

Description: A Randomized Controlled Trial Comparing Antibiotic Cement Bead Pouch versus Negative Pressure Wound Therapy for the Management of Severe Open Tibia Fracture Wounds.

Status: Currently enrolling

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BTI-203

Study Name: Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
Study Sponsor: BioAegis Therapeutics, Inc.
Principal Investigator: Radu Neamu, MD

Description: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Adjunctive Recombinant Human Plasma Gelsolin with Standard of Care for Moderate-to-Severe ARDS Due to Pneumonia or Other Infections.

Status: Currently enrolling

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CLP-03

Study Name: A Safety and Effectiveness Prospective Blinded Clinical Study to Validate xBar System as Monitoring Tool for Anastomotic Leaks Detection
Study Sponsor: Exero Medical Ltd
Principal Investigator: Michael Jobst, MD

Description: A Safety and Effectiveness Prospective Blinded Clinical Study to Validate xBar System as Monitoring Tool for Anastomotic Leaks Detection.

Status: Currently enrolling

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CORE-OLE

Study Name: CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)
Study Sponsor: Ionis Pharmaceuticals, Inc
Principal Investigator: Aaron Ward, MD

Description: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants with Severe Hypertriglyceridemia (SHTG).

Status: Active, not recruiting

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GATEWAY

Study Sponsor: Medtronic
Principal Investigator: Shannon Wakeley, MD

Description: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants with Severe Hypertriglyceridemia (SHTG).

Status: Enrollment beginning in December 2025

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HipAttack-2

Study Name: Hip Fracture Accelerated Care and Treatment Track
Study Sponsor: Population Health Research Institute
Principal Investigator: Alesha Scott, DO

Description: A multicentre, international, parallel group randomized controlled trial to determine whether accelerated surgery for hip fracture in patients with acute myocardial injury is superior to standard care in reducing death at 90 days after randomization.

Status: Currently enrolling

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M21-341

Study Name: A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants
Study Sponsor: AbbVie
Principal Investigator: Madeline Jones-Ryan, DO

Description: A Phase 2/3 multicenter, double blinded, randomized, dose-conversion, active control study examining the efficacy and safety of Armour Thyroid compared to synthetic T4 for the treatment of adults with primary hypothyroidism.

Status: Currently enrolling

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MIRA Surgical System Hysterectomy Study

Study Name: MIRA Surgical System for Umbrella Surgical Procedures: Minimally Invasive Benign Hysterectomy Clinical Study
Study Sponsor: Virtual Incision
Principal Investigator: Gregory Heidrick, MD

Description: MIRA Surgical System for Umbrella Surgical Procedures: Minimally Invasive Benign Hysterectomy Clinical Study.

Status: Currently enrolling

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MIRA Surgical System Registry Study

Study Name: MIRA Registry Study
Study Sponsor: Virtual Incision Corporation
Principal Investigator: Michael Jobst, MD

Description: MIRA Registry is a multicenter post-market, observational registry for the use of the MIRA Surgical System. This is an open label, single arm, prospective, multi-center cumulative database of patients who have undergone surgery using the MIRA Surgical System.

Status: Currently enrolling

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Completed Clinical Trials

The Bryan Clinical Research Center has completed the following clinical studies:

IMPACT2

Study Name: In-Home Study with MiniMed™ 780G Pump Automated Control in Type 2 - Evaluation of the AHCL System in Adults with Insulin-requiring Type 2 Diabetes
Study Sponsor: Medtronic
Principal Investigator: Shannon Wakeley, MD

Description: Type 2 diabetes mellitus, formerly known as non-insulin dependent diabetes and mature-onset diabetes, is characterized by a lack of insulin or insulin resistance In adults, type 2 diabetes accounts for 90–95% of all diagnosed cases of diabetes. The MiniMed 780G system is a closed loop insulin system. In addition to automatically adjusting the amount of insulin delivered based on sensor glucose readings, the MiniMed 780G insulin pump can also automatically deliver correction boluses as needed. The purpose of this study is to assess the safety and effectiveness of the MiniMed 780G system when used by adults with insulin-requiring type 2 diabetes. Patients with a clinical diagnosis of type 2 diabetes for 2 years or more, who are receiving 2 or more injections daily of long-acting insulin and rapid-acting analogs may be eligible for this study.

Status: Study completed - in follow up

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RESET-RA

Study Name: Vagus Nerve Stimulation Using the SetPoint System for Moderate to Severe Rheumatoid Arthritis
Study Sponsor: SetPoint Medical
Principal Investigator: Steven Gogela, MD and Melvin Churchill, MD

Description: Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with progressive joint damage, disability and systemic complications. There is an unmet medical need for alternative therapies for patients who fail to respond to or are intolerant of approved targeted agents. A medical device may offer a useful, alternative solution to patients, caregivers and healthcare payers. The SetPoint System is indicated for the treatment of adult patients with active, moderate to severe RA who have had an inadequate response or intolerance to 1 or more biologic or targeted synthetic anti-Inflammatory drugs. The SetPoint System comprises 2 implantable parts and 2 external parts. Patients with Rheumatoid Arthritis who have demonstrated an inadequate response, loss of response, or intolerance to 1 or more approved for RA may be eligible for this study.

Status: Study completed - in follow up

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SAFFRON

Study Name: Sacral Fracture Fusion/Fixation for Rapid Rehabilitation: Randomized Controlled Trial
Study Sponsor: SI-Bone
Principal Investigator: Steve Shannon, MD

Description: Sacral fractures can result in substantial pain and disability and unfortunately, the incidence of these fractures is increasing. This study will evaluate the effectiveness and safety of surgery to treat sacral fractures and sacroiliac (SI) joint fusion vs non-surgical management. Participants will be randomized to surgery using the iFuse-TORQ implant or non-surgical treatment. Patients with stable sacral fragility or insufficiency fractures may be eligible for this study.

Status: Study Completed

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VIRTUAL INCISION

Study Name: Virtual Incision Robotically Assisted Surgical Device (VI RASD) for Umbrella Surgical Procedures: Minimally Invasive Right and Left Colectomy
Study Sponsor: Virtual Incision
Principal Investigator: John Trapp, MD

Description:The Virtual Incision Robotically Assisted Surgical Device (VI RASD) is a medical device used to perform abdominal surgery through one small incision in the abdominal wall. The mini robot affords the surgeon with situational awareness and precision positioning of the instrumentation to traverse the anatomy, access the surgical target, and excise it for evaluation. The VI RASD is designed to perform surgery with improved ergonomics, flexible surgical robot positioning, triangulation built into the instrumentation and camera setup, and the ability of the surgeon to visualize the target surgical area from multiple angles in the body. Patients presenting with the medical and/or surgical indication for right or left colon are eligible for the study. 

Status: Completed Enrollment - in follow up

Talk with a coordinator

Call 402-481-1122 or enter your contact information below and we will connect you with one of our research coordinators.